Box C/D snoRNP assembly

Across TCGA pan-cancer cohorts, RNA activity of the Box C/D snoRNP assembly pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Box C/D snoRNP assembly pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and LGG, show the opposite pattern, with higher activity associated with better survival.

LIHC, ACC, and CESC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.701	0.825	<.001	74	view →
ACC	DFS	Tertile	All	0.111	0.663	<.001	54	view →
CESC	OS	Quartile	All	0.393	0.724	.003	50	view →
READ	OS	Tertile	All	1.000	0.845	<.001	48	view →
LGG	OS	Median	All	0.933	0.854	<.001	19	view →
CHOL	OS	Median	All	0.418	0.730	.013	18	view →
UVM	DFS	Median	III,IV	0.211	0.884	.002	18	view →
UCS	DFS	Quartile	II,III,IV	0.569	0.120	.013	14	view →
LUSC	DFS	Quartile	All	0.829	0.693	.008	12	view →
THCA	DFS	Tertile	IV	0.555	0.867	.023	7	view →
ESCA	DFS	Tertile	IV	0.785	0.372	.024	7	view →
KIRP	DFS	Tertile	III,IV	0.791	0.239	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0000492–LIHC (OS)

Open the LIHC breakdown →