"Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA cell cohorts, RNA activity of the "Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAGK, ATP6V0D1, and CD59, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" activity versus NAGK in LUNG_NSCLC_LUSC (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NAGK →	-1.165	-0.368	.003	<.001	3	6
LUNG_NSCLC_LUSC	ATP6V0D1 →	-0.902	-0.368	.008	<.001	3	5
LUNG_NSCLC_LUSC	CD59 →	-1.958	-0.368	.006	<.001	3	5
BREAST	LDHB →	+2.769	+0.132	.003	<.001	3	5
BREAST	FAM98C →	-0.764	-0.122	<.001	.006	2	6
BREAST	AMFR →	-0.907	-0.093	.002	.008	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000447 vs NAGK — LUNG_NSCLC_LUSC

Explore this scatter interactively →