"Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"

Across TCGA pan-cancer cohorts, RNA activity of the "Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher "Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and GBM, show the opposite pattern, with higher activity associated with better survival.

KIRC, KIRP, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.545	0.690	<.001	152	view →
KIRP	DFS	Tertile	All	0.754	0.947	<.001	52	view →
UCS	OS	Median	III,IV	0.570	0.210	.006	36	view →
UCEC	DFS	Median	All	0.858	0.931	<.001	32	view →
LUSC	DFS	Quartile	III,IV	0.061	0.992	<.001	23	view →
ESCA	DFS	Median	II,III,IV	0.397	0.595	.002	17	view →
GBM	DFS	Tertile	All	0.440	0.170	<.001	16	view →
READ	OS	Tertile	II,III,IV	0.828	0.423	.005	16	view →
PAAD	OS	Quartile	All	0.319	0.598	.013	16	view →
LGG	OS	Quartile	All	0.845	0.939	.001	16	view →
THCA	OS	Median	IV	0.562	1.000	.004	14	view →
UVM	DFS	Median	III,IV	0.211	0.884	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0000447–KIRC (OS)

Open the KIRC breakdown →