Spliceosomal conformational changes to generate catalytic conformation

Across TCGA patient cohorts, RNA activity of the Spliceosomal conformational changes to generate catalytic conformation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF148, GMPS, and RFC4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal conformational changes to generate catalytic conformation activity versus ZNF148 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF148 →	+0.283	+0.060	<.001	<.001	3	6
LUAD	GMPS →	+0.249	+0.043	<.001	<.001	3	6
LUAD	RFC4 →	+0.304	+0.041	<.001	<.001	3	5
LUAD	TMED4 →	-0.346	-0.051	.001	<.001	3	5
LUAD	WDHD1 →	+0.633	+0.043	<.001	.001	3	5
LUAD	MCM7 →	+0.668	+0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000393 vs ZNF148 — LSCC

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