Spliceosomal snRNP assembly

Across TCGA cell cohorts, RNA activity of the Spliceosomal snRNP assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HROB, SART3, and ILF3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spliceosomal snRNP assembly activity versus HROB in SOFT_TISSUE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HROB →	+0.831	+0.177	.007	<.001	3	7
SOFT_TISSUE	SART3 →	+0.742	+0.201	<.001	.005	3	7
BREAST	ILF3 →	+0.795	+0.292	<.001	<.001	3	7
KIDNEY	SPINDOC →	+1.192	+0.500	<.001	.004	3	7
LUNG_SCLC	POLE →	+0.742	+0.112	.005	.002	3	7
BLOOD_Leukemia	SF3A2 →	+0.471	+0.149	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000387 vs HROB — SOFT_TISSUE

Explore this scatter interactively →