"Regulation of alternative mRNA splicing, via spliceosome"

Across TCGA patient cohorts, RNA activity of the "Regulation of alternative mRNA splicing, via spliceosome" pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NNMT, FBXO27, and PDE1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of alternative mRNA splicing, via spliceosome" activity versus NNMT in OV (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NNMT →	-1.535	-0.204	.009	.001	3	5
BRCA	FBXO27 →	-0.861	-0.216	<.001	.001	3	5
GBM	PDE1A →	-0.698	-0.185	.005	.002	3	5
GBM	HTRA1 →	-0.882	-0.220	<.001	<.001	3	5
GBM	BEST1 →	-0.863	-0.275	<.001	<.001	3	5
GBM	SYNPO2 →	-0.724	-0.212	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000381 vs NNMT — OV

Explore this scatter interactively →