"Regulation of alternative mRNA splicing, via spliceosome"

Across TCGA pan-cancer cohorts, RNA activity of the "Regulation of alternative mRNA splicing, via spliceosome" pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 54 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher "Regulation of alternative mRNA splicing, via spliceosome" pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as COAD and READ, show the opposite pattern, with higher activity associated with better survival.

KIRC, KICH, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.560	0.731	.001	61	view →
KICH	DFS	Quartile	All	0.513	1.000	<.001	60	view →
UVM	DFS	Tertile	III,IV	0.206	0.929	<.001	58	view →
COAD	OS	Median	II,III,IV	0.869	0.689	.003	53	view →
READ	OS	Median	II,III,IV	0.900	0.305	<.001	50	view →
HNSC	OS	Median	III,IV	0.603	0.269	.002	45	view →
ACC	OS	Quartile	All	0.570	0.884	.001	38	view →
UCS	DFS	Median	IV	0.952	0.367	.001	34	view →
ESCA	OS	Median	III,IV	0.611	0.294	<.001	32	view →
KIRP	DFS	Tertile	All	0.566	0.774	<.001	31	view →
DLBC	DFS	Tertile	II,III,IV	0.079	0.984	.014	30	view →
SKCM	DFS	Quartile	All	0.300	0.175	.002	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0000381–KIRC (DFS)

Open the KIRC breakdown →