"Regulation of alternative mRNA splicing, via spliceosome"

Across TCGA cell cohorts, RNA activity of the "Regulation of alternative mRNA splicing, via spliceosome" pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALPG, OC90, and FLOT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALPG grouped by "Regulation of alternative mRNA splicing, via spliceosome"-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ALPG →	+0.199	+0.132	.002	.002	3	5
LUNG_NSCLC_LUSC	OC90 →	+0.240	+0.193	.005	<.001	3	4
LARGE_INTESTINE	FLOT1 →	+0.235	+0.148	.002	<.001	3	4
LUNG_NSCLC_LUSC	SIAH3 →	+0.298	+0.138	.002	.004	1	6
LUNG_NSCLC_LUSC	CLSTN2 →	+0.331	+0.191	<.001	.002	3	4
LUNG_NSCLC_LUSC	RNF149 →	+0.126	+0.154	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALPG by "Regulation of alternative mRNA splicing, via spliceosome" activity — SOFT_TISSUE

Explore this box plot interactively →