"Alternative mRNA splicing, via spliceosome"

Across TCGA patient cohorts, RNA activity of the "Alternative mRNA splicing, via spliceosome" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GATAD2B, RPRD2, and POGZ, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Alternative mRNA splicing, via spliceosome" activity versus GATAD2B in GBM (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GATAD2B →	+0.338	+0.042	.002	<.001	3	7
LUAD	RPRD2 →	+0.255	+0.049	<.001	<.001	3	6
HNSC	POGZ →	+0.275	+0.094	<.001	<.001	3	6
LSCC	ARID4B →	+0.201	+0.037	.006	.003	3	6
LSCC	ADAR →	+0.238	+0.030	.007	.006	3	6
PDAC	SDE2_S278 →	+0.501	+0.029	.005	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000380 vs GATAD2B — GBM

Explore this scatter interactively →