"Alternative mRNA splicing, via spliceosome"

Across TCGA pan-cancer cohorts, RNA activity of the "Alternative mRNA splicing, via spliceosome" pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 71 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher "Alternative mRNA splicing, via spliceosome" pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRC, ACC, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.545	0.709	<.001	105	view →
ACC	OS	Median	All	0.405	0.756	<.001	80	view →
READ	OS	Median	II,III,IV	0.888	0.314	<.001	65	view →
HNSC	OS	Median	All	0.828	0.715	.003	64	view →
KIRP	OS	Quartile	All	0.570	0.863	<.001	62	view →
UVM	DFS	Quartile	III,IV	0.180	0.854	<.001	58	view →
KICH	DFS	Quartile	All	0.422	1.000	<.001	51	view →
LIHC	OS	Median	All	0.606	0.787	<.001	46	view →
UCS	DFS	Median	IV	0.952	0.473	.018	40	view →
SCLC	OS	Tertile	III,IV	0.712	0.251	.002	35	view →
SKCM	OS	Median	IV	1.000	0.267	.003	32	view →
ESCA	OS	Tertile	III,IV	0.672	0.321	.006	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0000380–KIRC (DFS)

Open the KIRC breakdown →