"Alternative mRNA splicing, via spliceosome"

Across TCGA patient cohorts, RNA activity of the "Alternative mRNA splicing, via spliceosome" pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM15, SSRP1, and KHSRP_S480, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Alternative mRNA splicing, via spliceosome" activity versus RBM15 in BRCA (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RBM15 →	+0.221	+0.287	<.001	<.001	3	6
LSCC	SSRP1 →	+0.352	+0.199	.001	.002	3	5
OV	KHSRP_S480 →	+0.627	+0.221	<.001	<.001	3	5
COAD	SAP18 →	+0.226	+0.303	<.001	<.001	3	5
BRCA	SFPQ →	+0.154	+0.238	<.001	<.001	3	5
OV	SNRPD2 →	+0.377	+0.230	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000380 vs RBM15 — BRCA

Explore this scatter interactively →