"Alternative mRNA splicing, via spliceosome"

Across TCGA cell cohorts, RNA activity of the "Alternative mRNA splicing, via spliceosome" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT17, XRN1, and ASB14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUDT17 grouped by "Alternative mRNA splicing, via spliceosome"-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NUDT17 →	+1.156	+0.198	.002	.007	3	5
BREAST	XRN1 →	+0.675	+0.109	.001	<.001	3	5
SOFT_TISSUE	ASB14 →	+0.185	+0.136	.003	.003	3	5
BREAST	ZNF432 →	+0.901	+0.114	.001	<.001	3	5
BREAST	TOLLIP →	+0.878	+0.105	.005	.002	3	5
BLOOD_Leukemia	MST1 →	+1.702	+0.138	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUDT17 by "Alternative mRNA splicing, via spliceosome" activity — LIVER

Explore this box plot interactively →