"Alternative mRNA splicing, via spliceosome"

Across TCGA cell cohorts, RNA activity of the "Alternative mRNA splicing, via spliceosome" pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOP1A, MTA2, and INTS7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Alternative mRNA splicing, via spliceosome" activity versus DOP1A in URINARY_TRACT (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DOP1A →	+1.123	+0.209	<.001	<.001	3	7
LUNG_SCLC	MTA2 →	+0.418	+0.081	.001	.001	3	5
LUNG_NSCLC_LUSC	INTS7 →	+0.757	+0.237	.007	.002	3	5
LUNG_NSCLC_LUSC	TIGD1 →	+1.424	+0.346	.001	.001	3	5
STOMACH	UBR5 →	+0.837	+0.138	.009	.003	3	5
URINARY_TRACT	ZNF507 →	+0.536	+0.125	.004	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000380 vs DOP1A — URINARY_TRACT

Explore this scatter interactively →