Protein deneddylation

Across TCGA patient cohorts, RNA activity of the Protein deneddylation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BBX_S183, XRCC6, and DIS3L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein deneddylation activity versus BBX_S183 in BRCA (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BBX_S183 →	+0.513	+0.058	.005	.002	3	5
LSCC	XRCC6 →	+0.184	+0.031	.002	.003	3	4
OV	DIS3L2 →	+0.267	+0.043	.002	.001	3	4
CCRCC	EPS15_S324 →	-0.325	-0.030	<.001	.001	3	4
CCRCC	MAP9_S79 →	+0.441	+0.026	.003	<.001	3	4
PDAC	SPATS2L_S455 →	+0.325	+0.034	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000338 vs BBX_S183 — BRCA

Explore this scatter interactively →