Protein deneddylation

Across TCGA cell cohorts, RNA activity of the Protein deneddylation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX8, SLFN11, and ZNF460, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNX8 grouped by Protein deneddylation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SNX8 →	+1.043	+0.155	.004	.006	3	4
LUNG_NSCLC_LUSC	SLFN11 →	+3.283	+0.195	.003	<.001	3	4
LUNG_SCLC	ZNF460 →	+0.846	+0.148	.001	.007	3	4
KIDNEY	ADCK5 →	-0.640	-0.161	.001	<.001	3	4
OESOPHAGUS	SLC25A51 →	+0.830	+0.095	.004	.007	3	4
OESOPHAGUS	SH2D5 →	+1.671	+0.106	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNX8 by Protein deneddylation activity — LARGE_INTESTINE

Explore this box plot interactively →