"Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA cell cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCF2, LRP11, and ELK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus NCF2 in OESOPHAGUS (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NCF2 →	-1.951	-0.222	.001	.001	3	4
CNS	LRP11 →	-1.312	-0.212	.001	.003	2	5
OVARY	ELK1 →	+0.797	+0.227	.001	<.001	3	4
BONE	WASF1 →	+1.611	+0.221	.009	.003	3	4
BONE	CLPP →	+1.152	+0.307	<.001	<.001	3	4
BONE	ESRRA →	+1.037	+0.309	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000288 vs NCF2 — OESOPHAGUS

Explore this scatter interactively →