"Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA pan-cancer cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 69 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher "Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

ACC, HNSC, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.465	0.767	.002	73	view →
HNSC	DFS	Median	All	0.783	0.642	<.001	65	view →
UCS	DFS	Quartile	II,III,IV	0.653	0.166	.002	60	view →
READ	OS	Median	All	0.871	0.319	<.001	44	view →
KIRC	DFS	Quartile	III,IV	0.235	0.580	.004	35	view →
KIRP	DFS	Tertile	All	0.520	0.644	.005	24	view →
LUSC	DFS	Tertile	III,IV	0.121	0.853	<.001	18	view →
CESC	DFS	Median	II,III,IV	0.719	0.834	.023	16	view →
GBM	DFS	Quartile	All	0.577	0.209	.002	15	view →
LGG	DFS	Quartile	All	0.223	0.604	<.001	15	view →
DLBC	DFS	Quartile	All	0.458	0.888	.005	13	view →
OV	DFS	Tertile	IV	0.324	0.671	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0000288–ACC (DFS)

Open the ACC breakdown →