Polysaccharide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Polysaccharide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN1, MSRB3, and SYNPO2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polysaccharide biosynthetic process activity versus CNN1 in LUAD (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CNN1 →	+0.759	+0.355	.002	.001	3	7
UCEC	MSRB3 →	+1.001	+0.205	.002	<.001	3	7
UCEC	SYNPO2 →	+1.094	+0.192	.002	.002	3	7
LSCC	TAGLN →	+0.697	+0.332	<.001	<.001	3	6
LSCC	SPARCL1 →	+0.803	+0.452	<.001	<.001	3	6
UCEC	LMOD1 →	+1.467	+0.189	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000271 vs CNN1 — LUAD

Explore this scatter interactively →