Spliceosomal tri-snRNP complex assembly

Across TCGA cell cohorts, RNA activity of the Spliceosomal tri-snRNP complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1E, C8orf33, and CENPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSNK1E grouped by Spliceosomal tri-snRNP complex assembly-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CSNK1E →	+0.504	+0.265	.001	.004	2	6
KIDNEY	C8orf33 →	-0.858	-0.255	<.001	<.001	3	5
CNS	CENPA →	-0.457	-0.169	.007	.002	3	5
BLOOD_Leukemia	PPP1R8 →	-0.712	-0.251	<.001	<.001	3	4
PANCREAS	CIT →	-0.921	-0.335	.008	.009	3	4
BLOOD_Leukemia	GMEB1 →	-0.504	-0.152	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSNK1E by Spliceosomal tri-snRNP complex assembly activity — PANCREAS

Explore this box plot interactively →