Spliceosomal tri-snRNP complex assembly

Across TCGA pan-cancer cohorts, RNA activity of the Spliceosomal tri-snRNP complex assembly pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 26 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Spliceosomal tri-snRNP complex assembly pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

ACC, UCEC, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	II,III,IV	0.313	0.752	.002	34	view →
UCEC	DFS	Tertile	All	0.644	0.748	.011	30	view →
HNSC	DFS	Quartile	All	0.772	0.640	.014	25	view →
BLCA	DFS	Quartile	All	0.156	0.524	.005	22	view →
DLBC	DFS	Quartile	All	0.604	1.000	.011	21	view →
STAD	OS	Quartile	All	0.218	0.582	.005	18	view →
SKCM	OS	Tertile	IV	0.867	0.215	.004	18	view →
LGG	OS	Quartile	All	0.685	0.869	<.001	16	view →
LUAD	DFS	Tertile	IV	0.480	0.976	.038	12	view →
BRCA	OS	Quartile	IV	0.851	0.300	.016	12	view →
LIHC	DFS	Quartile	III,IV	0.352	0.059	.024	12	view →
PAAD	DFS	Quartile	II,III,IV	0.551	0.257	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0000244–ACC (DFS)

Open the ACC breakdown →