Meiotic spindle organization

Across TCGA cell cohorts, RNA activity of the Meiotic spindle organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP4B1, OVOL1, and TMEM30B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic spindle organization activity versus CYP4B1 in BREAST (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CYP4B1 →	+1.546	+0.170	.009	.006	3	6
BREAST	OVOL1 →	+1.718	+0.282	.003	<.001	3	6
LUNG_SCLC	TMEM30B →	+2.417	+0.191	<.001	<.001	3	6
LUNG_NSCLC_LUAD	LIX1L →	-1.685	-0.163	<.001	<.001	3	6
LUNG_NSCLC_LUAD	PRSS8 →	+3.546	+0.225	<.001	<.001	3	6
LUNG_SCLC	STX19 →	+1.618	+0.234	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000212 vs CYP4B1 — BREAST

Explore this scatter interactively →