Meiotic spindle organization

Across TCGA pan-cancer cohorts, RNA activity of the Meiotic spindle organization pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Meiotic spindle organization pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as THYM and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRP, ACC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.494	0.811	<.001	157	view →
ACC	OS	Median	All	0.652	0.924	<.001	140	view →
MESO	OS	Median	All	0.374	0.686	<.001	129	view →
KIRC	OS	Median	All	0.494	0.718	<.001	106	view →
LIHC	OS	Tertile	All	0.672	0.842	<.001	71	view →
UVM	DFS	Tertile	II,III,IV	0.236	0.794	<.001	64	view →
UCEC	DFS	Median	All	0.782	0.882	<.001	46	view →
THCA	DFS	Tertile	III,IV	0.809	0.988	<.001	46	view →
LGG	OS	Median	All	0.740	0.876	<.001	37	view →
LUAD	OS	Median	All	0.762	0.857	.001	34	view →
COAD	DFS	Median	II,III,IV	0.700	0.797	.009	27	view →
PRAD	OS	Median	All	0.976	1.000	.011	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0000212–KIRP (OS)

Open the KIRP breakdown →