ZYX

Across TCGA patient cohorts, ZYX mutation is significantly associated with the RNA expression of many other genes, with 1,700 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZYX-associated genes across cancer lineages are CDRT15P7, DCANP1, and TMEM225. Each is linked with ZYX in more than 1 cancer types. Because this analysis shows association rather than direction, both ZYX-to-partner and partner-to-ZYX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDRT15P7 grouped by ZYX-low versus ZYX-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZYX→partner) and Y-score (partner→ZYX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	CDRT15P7 →	+0.078	+5.669	<.001	.003	3	2
COAD	DCANP1 →	+0.013	+4.790	.003	.006	3	2
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	2
READ	NPLP1 →	+0.291	+5.421	<.001	.005	3	2
READ	LINC00927 →	+0.015	+5.039	<.001	.008	3	2
BLCA	HMGN1P31 →	+0.100	+5.033	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,700 associations by consensus.

CDRT15P7 by ZYX expression — CESC

Explore this box plot interactively →