ZYX

Across TCGA pan-cancer cohorts, ZYX RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ZYX’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZYX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZYX is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where ZYX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZYX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.952	<.001	12	view →
KIRP	Male	III,IV	+1.538	<.001	11	view →
KIRC	Female	All	+1.000	<.001	11	view →
COAD	Female	III,IV	+1.174	<.001	9	view →
KICH	Female	All	−1.596	<.001	8	view →
THCA	Male	III,IV	+1.097	<.001	8	view →
BLCA	All	III,IV	−1.115	.001	7	view →
LIHC	Female	II,III,IV	+1.516	<.001	6	view →
UCEC	All	All	−1.408	<.001	6	view →
LUSC	All	II,III,IV	−0.749	<.001	6	view →
CHOL	Male	All	+2.231	<.001	4	view →
LUAD	Male	All	−0.815	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ZYX–HNSC

Open the HNSC breakdown →