ZYX

Across TCGA patient cohorts, ZYX mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ZYX-associated genes across cancer lineages are Lck, Caspase-7-cleavedD198, and EGFR. Each is linked with ZYX in more than 1 cancer types. Because this analysis shows association rather than direction, both ZYX-to-partner and partner-to-ZYX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by ZYX-low versus ZYX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZYX→partner) and Y-score (partner→ZYX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.197	+1.700	.020	.044	3	2
UCEC	Caspase-7-cleavedD198 →	+0.835	+2.720	<.001	.003	3	2
SKCM	EGFR →	-0.172	-2.321	.034	.035	3	1
SKCM	ACC_pS79 →	+0.293	+3.000	.042	.034	3	1
SKCM	Heregulin →	+0.263	+2.820	.002	.035	3	1
SKCM	p38-MAPK →	-0.357	-2.983	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Lck by ZYX expression — UCEC

Explore this box plot interactively →