ZYX

Across TCGA cell cohorts, ZYX mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZYX-associated genes across cancer lineages are RASGEF1C, GABRG1, and SHE. Each is linked with ZYX in more than 1 cancer types. Because this analysis shows association rather than direction, both ZYX-to-partner and partner-to-ZYX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASGEF1C grouped by ZYX-low versus ZYX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZYX→partner) and Y-score (partner→ZYX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RASGEF1C →	+0.216	+3.404	.003	.006	3	1
LARGE_INTESTINE	GABRG1 →	+0.008	+2.933	.002	.003	3	1
LARGE_INTESTINE	SHE →	+0.107	+3.321	.001	.005	3	1
LARGE_INTESTINE	C9orf135 →	+0.086	+3.141	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

RASGEF1C by ZYX expression — LARGE_INTESTINE

Explore this box plot interactively →