Across TCGA cell cohorts, ZYG11A mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZYG11A-associated genes across cancer lineages are SCGB1C1, OR4A47, and GRIA3. Each is linked with ZYG11A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZYG11A-to-partner and partner-to-ZYG11A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZYG11A→partner) and Y-score (partner→ZYG11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SCGB1C1 →	+0.204	+4.981	<.001	.008	3	1
CNS	OR4A47 →	+0.036	+6.357	<.001	<.001	3	1
BLOOD_Leukemia	GRIA3 →	+0.715	+3.579	.001	.007	3	1
BLOOD_Leukemia	ZSWIM2 →	+0.018	+3.239	.007	.004	3	1
BLOOD_Leukemia	C1orf189 →	+0.140	+3.540	.001	.005	3	1
BLOOD_Leukemia	GIMD1 →	+0.030	+2.982	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

ZYG11A survival (RNA) · tumor vs normal (RNA) · all ZYG11A data types