Across TCGA pan-cancer cohorts, ZYG11A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ZYG11A data layer compared with 2 for mutation status.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZYG11A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZYG11A expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.
HNSC, ACC, and SCLC are the cancer types where ZYG11A RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.