ZW10

Across TCGA patient cohorts, ZW10 mutation is significantly associated with the RNA expression of many other genes, with 2,898 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZW10-associated genes across cancer lineages are RNA5SP413, RNU6-669P, and RNU6-598P. Each is linked with ZW10 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZW10-to-partner and partner-to-ZW10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by ZW10-low versus ZW10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZW10→partner) and Y-score (partner→ZW10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP413 →	+0.794	+1.829	<.001	.001	3	3
THCA	RNU6-669P →	+0.208	+7.962	<.001	.007	3	2
LIHC	RNU6-598P →	+0.511	+5.033	<.001	.009	3	2
LGG	HSPD1P14 →	+0.057	+5.127	<.001	.001	3	2
LGG	RPS20P25 →	+0.090	+5.032	<.001	.004	3	2
UCEC	H3Y2 →	+0.346	+1.584	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,898 associations by consensus.

RNA5SP413 by ZW10 expression — UCEC

Explore this box plot interactively →