ZW10

Across TCGA pan-cancer cohorts, ZW10 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZW10’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ZW10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZW10 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, HNSC, and LIHC are the cancer types where ZW10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZW10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.525	<.001	10	view →
HNSC	All	All	+0.424	<.001	10	view →
LIHC	Male	II,III,IV	+0.919	<.001	9	view →
STAD	All	II,III,IV	+0.780	<.001	9	view →
COAD	All	II,III,IV	+0.565	<.001	9	view →
LUAD	Male	II,III,IV	+0.793	<.001	7	view →
LUSC	Female	All	+0.912	<.001	6	view →
THCA	All	All	−0.252	.001	6	view →
CHOL	Male	All	+1.378	<.001	4	view →
BRCA	All	All	+0.195	.004	4	view →
ESCA	Female	All	+1.136	.028	2	view →
READ	All	All	+0.375	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZW10–BLCA

Open the BLCA breakdown →