ZW10

Across TCGA cell cohorts, ZW10 mutation is significantly associated with the RNA expression of many other genes, with 141 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZW10-associated genes across cancer lineages are ZAN, HMGXB4, and S100PBP. Each is linked with ZW10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZW10-to-partner and partner-to-ZW10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by ZW10-low versus ZW10-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZW10→partner) and Y-score (partner→ZW10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZAN →	+0.006	+5.087	<.001	.004	3	1
LARGE_INTESTINE	HMGXB4 →	+0.525	+3.364	.008	.002	3	1
LARGE_INTESTINE	S100PBP →	+0.712	+3.364	.002	.002	3	1
LARGE_INTESTINE	FBXO30 →	+0.485	+3.364	.004	.002	3	1
LARGE_INTESTINE	SLC17A5 →	+0.793	+3.364	.001	.002	3	1
LARGE_INTESTINE	LYPLA1 →	+0.638	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 141 associations by consensus.

ZAN by ZW10 expression — URINARY_TRACT

Explore this box plot interactively →