ZW10

Across TCGA cell cohorts, ZW10 mutation is significantly associated with the mutation status of many other genes, with 3,551 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZW10-associated genes across cancer lineages are MYH13, TBX21, and MEGF8. Each is linked with ZW10 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZW10-to-partner and partner-to-ZW10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH13 grouped by ZW10-low versus ZW10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZW10→partner) and Y-score (partner→ZW10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYH13 →	+2.582	+3.377	.001	.001	1	3
BLOOD_Leukemia	TBX21 →	+3.845	+3.548	.003	.003	1	3
LUNG_NSCLC_LUAD	MEGF8 →	+2.911	+3.750	.002	.002	1	3
LUNG_NSCLC_LUAD	ERF →	+5.303	+4.339	<.001	<.001	1	3
LUNG_NSCLC_LUAD	GAB1 →	+4.303	+4.000	.001	.001	1	3
LUNG_NSCLC_LUAD	TNS2 →	+3.303	+3.478	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,551 associations by consensus.

MYH13 by ZW10 expression — BLOOD_Leukemia

Explore this box plot interactively →