ZSWIM2

Across TCGA patient cohorts, ZSWIM2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM2-associated genes across cancer lineages are JNK_pT183_Y185, mTOR_pS2448, and p38-MAPK_pT180_Y182. Each is linked with ZSWIM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZSWIM2-to-partner and partner-to-ZSWIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ZSWIM2-low versus ZSWIM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM2→partner) and Y-score (partner→ZSWIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.181	-3.584	.003	.002	3	3
LUAD	mTOR_pS2448 →	-0.247	-2.321	.006	.035	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.523	-1.489	.001	.030	3	2
LUAD	STAT3_pY705 →	-0.504	-3.169	<.001	.018	2	3
UCEC	C-Raf →	+0.195	+2.247	<.001	.001	3	2
LUAD	53BP1 →	+0.361	+2.321	.009	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

JNK_pT183_Y185 by ZSWIM2 expression — UCEC

Explore this box plot interactively →