ZSWIM2

Across TCGA pan-cancer cohorts, ZSWIM2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZSWIM2’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where ZSWIM2 RNA is repressed in tumor relative to normal tissue. In most cancer types ZSWIM2 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and KIRC are the cancer types where ZSWIM2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZSWIM2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.039	.013	4	view →
KICH	All	All	−0.040	.010	3	view →
KIRC	Male	II,III,IV	−0.016	.006	3	view →
THCA	All	II,III,IV	+0.009	.019	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZSWIM2–BRCA

Open the BRCA breakdown →