ZSWIM2

Across TCGA cell cohorts, ZSWIM2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ZSWIM2-associated genes across cancer lineages are PRR27, KRTAP5-6, and C8A. Each is linked with ZSWIM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSWIM2-to-partner and partner-to-ZSWIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR27 grouped by ZSWIM2-low versus ZSWIM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM2→partner) and Y-score (partner→ZSWIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRR27 →	+0.197	+4.054	<.001	.004	3	2
SKIN	KRTAP5-6 →	+0.039	+3.297	<.001	.002	3	2
LARGE_INTESTINE	C8A →	+0.031	+3.684	<.001	.006	3	1
LUNG_SCLC	APOA4 →	+0.580	+3.898	<.001	.005	3	1
LUNG_SCLC	IL36A →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	SMCP →	+0.038	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

PRR27 by ZSWIM2 expression — LARGE_INTESTINE

Explore this box plot interactively →