zinc finger and SCAN domain containing 5BGenealiases: ZNF371 · ZNF495B
Q-omics provides the consensus-scored ZSCAN5B profile across patient tissues and cancer cell-line models. ZSCAN5B expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, ZSCAN5B is differentially expressed in 5, with the highest sampling consensus in THCA. Additionally, ZSCAN5B RNA expression shows 8,425 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRP, THCA, and TGCT as cancer lineages where ZSCAN5B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZSCAN5B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZSCAN5B survival associations across molecular data types. ZSCAN5B RNA expression shows survival associations in the most cancer types (26), followed by mutation status (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZSCAN5B RNA expression–survival associations across cancer types. High ZSCAN5B expression shows unfavorable associations in LIHC, ESCA and MESO, but favorable associations in KIRP, UVM and HNSC. The KIRP Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .002). Together, the overview and detailed table identify KIRP as the clearest survival context for ZSCAN5B RNA expression.
This table summarizes ZSCAN5B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for ZSCAN5B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZSCAN5B shows lower tumor expression in THCA, COAD and LUAD and higher tumor expression in KIRP and KIRC. The THCA box plot shows higher ZSCAN5B RNA expression in normal versus tumor tissue (log2 FC = −0.117, t-test p < 0.001).
This table shows molecular features associated with ZSCAN5B in patient tissues and cancer cell lines. In patient samples, ZSCAN5B shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, ZSCAN5B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and LARGE_INTESTINE.
