ZSCAN5A

Across TCGA patient cohorts, ZSCAN5A mutation is significantly associated with the RNA expression of many other genes, with 1,450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN5A-associated genes across cancer lineages are RNU6-1092P, HSFY4P, and SNORD115-21. Each is linked with ZSCAN5A in more than 2 cancer types. Because this analysis shows association rather than direction, both ZSCAN5A-to-partner and partner-to-ZSCAN5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1092P grouped by ZSCAN5A-low versus ZSCAN5A-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN5A→partner) and Y-score (partner→ZSCAN5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU6-1092P →	+0.459	+5.093	<.001	.008	3	3
LUAD	HSFY4P →	+0.022	+5.000	.004	.003	3	3
CESC	SNORD115-21 →	+0.486	+6.584	<.001	<.001	3	2
CESC	RNU6-644P →	+0.364	+4.193	.002	.009	3	2
CESC	ADGRF5-AS1 →	+0.038	+4.539	<.001	.008	3	2
CESC	RPL12P45 →	+0.218	+4.503	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,450 associations by consensus.

RNU6-1092P by ZSCAN5A expression — LGG

Explore this box plot interactively →