ZSCAN5A

Across TCGA pan-cancer cohorts, ZSCAN5A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ZSCAN5A data layer compared with 5 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher ZSCAN5A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZSCAN5A expression acts as an unfavorable survival marker, although some lineages such as COAD and UVM show a favorable association.

LGG, ACC, and MESO are the cancer types where ZSCAN5A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.626	0.849	<.001	54	view →
ACC	OS	Tertile	All	0.809	0.967	.002	49	view →
MESO	OS	Tertile	All	0.320	0.565	.002	44	view →
COAD	OS	Tertile	II,III,IV	0.674	0.498	.008	38	view →
UVM	OS	Quartile	All	0.871	0.460	.002	35	view →
READ	OS	Tertile	All	0.918	0.349	.001	30	view →
HNSC	DFS	Quartile	IV	0.768	0.538	<.001	24	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	23	view →
LIHC	OS	Tertile	II,III,IV	0.363	0.699	.001	19	view →
UCS	DFS	Quartile	II,III,IV	0.620	0.154	<.001	18	view →
SKCM	DFS	Quartile	III,IV	0.125	0.554	.001	18	view →
KIRC	OS	Tertile	All	0.705	0.551	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ZSCAN5A–LGG (DFS)

Open the LGG breakdown →