ZPBP

Across TCGA cell cohorts, ZPBP mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZPBP-associated genes across cancer lineages are SCGB1C1, BHLHA9, and KHDC3L. Each is linked with ZPBP in more than 1 cancer types. Because this analysis shows association rather than direction, both ZPBP-to-partner and partner-to-ZPBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C1 grouped by ZPBP-low versus ZPBP-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZPBP→partner) and Y-score (partner→ZPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SCGB1C1 →	+0.055	+4.977	<.001	.002	3	1
SOFT_TISSUE	BHLHA9 →	+0.027	+4.977	<.001	.002	3	1
SKIN	KHDC3L →	+0.015	+3.632	.001	.003	3	1
SKIN	NCR2 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	KLF1 →	+0.086	+3.215	.003	.009	3	1
LARGE_INTESTINE	RHOXF2 →	+0.034	+2.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SCGB1C1 by ZPBP expression — SOFT_TISSUE

Explore this box plot interactively →