ZP2

Across TCGA patient cohorts, ZP2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZP2-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and p62 Lck ligand. Each is linked with ZP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZP2-to-partner and partner-to-ZP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZP2-low versus ZP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZP2→partner) and Y-score (partner→ZP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.715	+1.807	<.001	.004	3	3
UCEC	MEK1 →	+0.404	+2.137	.001	.001	3	2
UCEC	p62 Lck ligand →	+0.258	+1.514	.020	.015	3	2
UCEC	Rb_pS807_S811 →	+0.293	+1.807	.034	.004	3	2
UCEC	VHL →	-0.564	-1.502	.014	.027	3	2
UCEC	ASNS →	+0.493	+2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by ZP2 expression — UCEC

Explore this box plot interactively →