ZP2

Across TCGA pan-cancer cohorts, ZP2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZP2 RNA is repressed in tumor relative to normal tissue. In most cancer types ZP2 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where ZP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.215	<.001	11	view →
THCA	Female	All	−0.083	<.001	11	view →
KIRP	Male	All	−0.207	<.001	7	view →
LUSC	All	All	−0.124	<.001	7	view →
HNSC	All	All	−0.168	.018	5	view →
LUAD	Female	II,III,IV	−0.144	.008	4	view →
COAD	All	All	+0.273	.011	2	view →
KICH	All	All	−0.150	.006	2	view →
UCEC	All	All	−0.133	.027	2	view →
PRAD	All	All	−0.116	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZP2–KIRC

Open the KIRC breakdown →