ZP2

Across TCGA cell cohorts, ZP2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ZP2-associated genes across cancer lineages are OR1E2, PRSS55, and KRTAP1-3. Each is linked with ZP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZP2-to-partner and partner-to-ZP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1E2 grouped by ZP2-low versus ZP2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZP2→partner) and Y-score (partner→ZP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1E2 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRSS55 →	+0.026	+4.247	<.001	.006	3	1
LUNG_NSCLC_LUAD	KRTAP1-3 →	+0.043	+4.959	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PYDC2 →	+0.154	+4.681	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.239	+3.103	.001	.004	3	1
LARGE_INTESTINE	PNMA3 →	+0.183	+2.781	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

OR1E2 by ZP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →