ZNF879

Across TCGA patient cohorts, ZNF879 mutation is significantly associated with the RNA expression of many other genes, with 2,186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF879-associated genes across cancer lineages are GZMH, ADNP2, and CEP76. Each is linked with ZNF879 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF879-to-partner and partner-to-ZNF879 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMH grouped by ZNF879-low versus ZNF879-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF879→partner) and Y-score (partner→ZNF879) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GZMH →	+0.972	+1.879	<.001	<.001	3	2
UCEC	ADNP2 →	+0.399	+1.692	.005	.003	3	2
UCEC	CEP76 →	+0.301	+1.958	.005	.002	3	2
UCEC	RAB11A →	+0.294	+1.921	.006	.003	3	2
UCEC	LEPROTL1 →	+0.345	+2.447	<.001	.001	3	2
UCEC	SLC25A11 →	+0.282	+2.412	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,186 associations by consensus.

GZMH by ZNF879 expression — UCEC

Explore this box plot interactively →