ZNF879

Across TCGA pan-cancer cohorts, ZNF879 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF879’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZNF879 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF879 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and THCA are the cancer types where ZNF879 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF879 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.561	<.001	11	view →
HNSC	Female	All	−0.583	<.001	10	view →
THCA	All	II,III,IV	−0.488	<.001	10	view →
UCEC	All	All	−0.561	<.001	6	view →
COAD	All	II,III,IV	−0.377	<.001	5	view →
CHOL	All	All	+0.595	.005	2	view →
STAD	Female	All	−0.461	.033	2	view →
LUSC	Male	All	−0.350	.012	2	view →
PRAD	All	All	−0.293	<.001	2	view →
KIRP	All	All	−0.252	.027	2	view →
BLCA	Male	IV	−0.587	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF879–KICH

Open the KICH breakdown →