ZNF879

Across TCGA pan-cancer cohorts, ZNF879 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ZNF879 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZNF879 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF879 expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

KIRC, MESO, and LUAD are the cancer types where ZNF879 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.907	0.840	<.001	119	view →
MESO	OS	Median	All	0.501	0.282	<.001	76	view →
LUAD	DFS	Tertile	All	0.747	0.499	<.001	71	view →
PAAD	DFS	Tertile	All	0.581	0.361	<.001	59	view →
ACC	OS	Quartile	II,III,IV	0.858	0.332	.002	49	view →
UCS	DFS	Median	IV	0.952	0.367	.001	44	view →
HNSC	DFS	Quartile	IV	0.753	0.515	<.001	40	view →
KIRP	DFS	Median	IV	0.038	0.527	.010	32	view →
LGG	OS	Tertile	All	0.701	0.847	<.001	25	view →
UCEC	DFS	Median	All	0.596	0.676	.006	20	view →
COAD	DFS	Quartile	II,III,IV	0.610	0.835	.006	12	view →
ESCA	OS	Median	III,IV	0.692	0.454	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ZNF879–KIRC (OS)

Open the KIRC breakdown →