ZNF879

Across TCGA cell cohorts, ZNF879 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZNF879-associated genes across cancer lineages are MMP26, OR10H5, and TPPP2. Each is linked with ZNF879 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF879-to-partner and partner-to-ZNF879 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by ZNF879-low versus ZNF879-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF879→partner) and Y-score (partner→ZNF879) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MMP26 →	+0.013	+4.022	<.001	.006	3	1
SKIN	OR10H5 →	+0.011	+3.977	<.001	.001	3	1
SKIN	TPPP2 →	+0.051	+3.632	<.001	.003	3	1
SKIN	LCE4A →	+0.031	+4.022	<.001	.006	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PRR23B →	+0.005	+4.217	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MMP26 by ZNF879 expression — SKIN

Explore this box plot interactively →