ZNF77

Across TCGA patient cohorts, ZNF77 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF77-associated genes across cancer lineages are CD49b, Notch1, and Caspase-8. Each is linked with ZNF77 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF77-to-partner and partner-to-ZNF77 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by ZNF77-low versus ZNF77-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF77→partner) and Y-score (partner→ZNF77) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD49b →	-0.245	-2.986	.037	.035	3	3
UCEC	Notch1 →	+0.235	+3.335	<.001	.005	3	2
UCEC	Caspase-8 →	-0.265	-3.673	.010	.001	3	2
UCEC	C-Raf →	+0.146	+1.807	.013	.027	3	2
UCEC	FoxM1 →	+0.238	+4.087	.026	<.001	3	1
UCEC	PCNA →	+0.286	+2.321	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CD49b by ZNF77 expression — UCEC

Explore this box plot interactively →