ZNF77

Across TCGA pan-cancer cohorts, ZNF77 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZNF77’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZNF77 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF77 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

LIHC, COAD, and THCA are the cancer types where ZNF77 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF77 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.879	<.001	9	view →
COAD	Female	All	+0.712	<.001	9	view →
THCA	Male	II,III,IV	−0.602	<.001	9	view →
STAD	All	II,III,IV	+0.476	.004	6	view →
KIRC	All	II,III,IV	−0.317	.002	6	view →
BLCA	All	All	+0.620	.004	5	view →
ESCA	All	II,III,IV	+0.475	.025	4	view →
UCEC	All	All	+0.408	.019	4	view →
LUSC	Male	All	+0.399	<.001	4	view →
CHOL	Female	All	+1.593	<.001	3	view →
HNSC	Male	III,IV	+0.494	.016	3	view →
READ	Male	All	+0.650	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZNF77–LIHC

Open the LIHC breakdown →