ZNF728

Across TCGA patient cohorts, ZNF728 mutation is significantly associated with the RNA expression of many other genes, with 2,788 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF728-associated genes across cancer lineages are SETP22, NARS1P2, and VPS26C. Each is linked with ZNF728 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF728-to-partner and partner-to-ZNF728 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SETP22 grouped by ZNF728-low versus ZNF728-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF728→partner) and Y-score (partner→ZNF728) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SETP22 →	+0.162	+3.462	<.001	<.001	3	3
COAD	NARS1P2 →	+0.434	+4.246	<.001	<.001	3	3
UCEC	VPS26C →	+0.332	+1.922	.008	.009	3	3
LUAD	HMGB3P11 →	+0.059	+2.223	.007	.008	3	3
UCEC	MSC →	+0.674	+2.534	.004	<.001	3	2
UCEC	C9orf50 →	-0.411	-3.584	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,788 associations by consensus.

SETP22 by ZNF728 expression — UCEC

Explore this box plot interactively →