ZNF728

Across TCGA pan-cancer cohorts, ZNF728 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ZNF728 data layer compared with 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF728 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF728 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UVM show a favorable association.

LUAD, UVM, and MESO are the cancer types where ZNF728 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.447	0.276	<.001	78	view →
UVM	OS	Quartile	II,III,IV	0.833	0.489	.006	51	view →
MESO	OS	Median	III,IV	0.705	0.430	.001	45	view →
LUSC	OS	Median	III,IV	0.233	0.778	.003	45	view →
ACC	DFS	Median	II,III,IV	0.700	0.313	.004	32	view →
UCS	OS	Tertile	IV	0.224	0.738	.010	30	view →
ESCA	OS	Tertile	III,IV	0.762	0.286	.001	25	view →
BRCA	DFS	Tertile	III,IV	0.865	0.715	.006	24	view →
READ	OS	Median	III,IV	0.596	0.886	.003	20	view →
SKCM	OS	Quartile	IV	0.218	0.867	.006	18	view →
CHOL	DFS	Tertile	All	0.901	0.253	.001	17	view →
PRAD	DFS	Quartile	All	0.961	0.877	.014	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ZNF728–LUAD (OS)

Open the LUAD breakdown →